Peripheral nerve injury is a devastating complication that can lead to complete functional loss or permanent impairment. Despite signiﬁcant advances in the repair of peripheral nerves, the functional recovery of these nerves never returns to the pre-injury state. Therefore, there have been many experimental trials to repair injured nerves. Recently, alternative materials embedded with regenerative cells were evaluated.
Stem cell-based therapies have appeared as a promising strategy for injured tissue regeneration. Recently, we reported the higher angiogenic and chemotactic properties of amniotic membrane-derived mesenchymal stem cells (AMMs) compared to adipose tis-sue-derived MSCs (ADMs). However, the therapeutic potential of AMMs in peripheral nerve injury has not been fully elucidated. In this study, we determined whether neuropathy can be ameliorated by the local transplantation of AMMs.