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June 25Regenerative Repair of Damaged Meniscus with Autologous Adipose Tissue-Derived Stem Cells

Articles, Knee Pain

A 32-year-old female was been experiencing left knee pain for the last two years prior to the office visit. The patient denied any history of significant trauma, except exercising on a treadmill. On the day of the initial evaluation, she reported moderate pain. She also complained of mild knee swelling. On physical examination, there were mild knee joint edema, minimally decreased range of motion, and mild tenderness with flexion. An MRI showed Grade II meniscal tear. Owing to continuous pain, the patient initially tried treatments comprising nonsteroidal anti-inflammatory drugs, physical therapy, PRP, and hyaluronic acid. However, these therapies failed.
When such conservative treatment fails, an arthroscopic resection of the meniscus was necessary. The major drawback of the meniscectomy is the early onset of osteoarthritis of the knee. With the increasing recognition of the meniscus as an important structure of the knee, meniscal repair has become the preferred treatment of choice over meniscectomy.
Being aware of the fact that adipose-derived stem cells (ASC) have been allowed, and being wary of the possibility of early onset of osteoarthritis, the patient wanted to try autologous non-cultured ASC mixture-based treatments for the repair of the damaged meniscus.
After obtaining autologous ASCs and preparing PRP as previously described, the ASC mixture was percutaneously injected under the ultrasound guidance into the knee joint of the patient. Three months after the treatment, the patient’s symptoms improved and and repeated MRI showed almost complete disappearance of the torn meniscus.

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