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Research Articles

October 3INtra-articular delivery of purified mesenchymal stem cells prevents post-traumatic arthritis

Articles, Hip Pain

Joint injury dramatically enhances the onset of osteoarthritis (OA) and is responsible for an estimated 12% of QA. Download article here.

October 3Hip capsular treated with PRP and BMC 0912

Articles, Hip Pain

Recently, orthobiologics have shown promise in the treatment of musculoskeletal soft tissue injuries and may have the potential to treat soft tissue injuries around the hip. Bone marrow aspiration concentrate (BMAC) and platelet-rich plasma (PRP) are two such therapies. Bone marrow aspirate concentrate contains mesenchymal stem cells which have anti-inflammatory, anti-apoptotic and multipotent capabilities. They read more

June 26192 Things The NFL has in common with STEM CELLS

Articles, Uncategorized

When your livelihood depends on your body’s performance, you can’t afford to be out of the game for too long. Just like the former Jets’ running back, Chris Johnson, hundreds of athletes are turning to newer alternative therapies to reduce their recovery time so they can get back into the game. More than a hundred read more

June 25Autologous Mesenchymal Stem Cell Treatment – Knee Osteoarthritis

Articles, Knee Pain

This study was a phase one clinical trial in which six patients with radiologic evidence of knee osteoarthritis (OA) that required joint replacement surgery were recruited. The main objective of this phase was to evaluate treatment safety. A large controlled trial, however, is necessary to compare intra-articular MSC injection with standard of care. In conclusion, read more

June 25Regenerative Repair of Damaged Meniscus with Autologous Adipose Tissue-Derived Stem Cells

Articles, Knee Pain

A 32-year-old female was been experiencing left knee pain for the last two years prior to the office visit. The patient denied any history of significant trauma, except exercising on a treadmill. On the day of the initial evaluation, she reported moderate pain. She also complained of mild knee swelling. On physical examination, there were read more

June 25Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells

Articles, Shoulder Pain

To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC). Fourteen consecutive patients with complete rotator cuff tears were fixed by trans-osseous stitches through mini-open incision, with subsequent injection of BMMC into the tendon borders, obtained from the iliac crest just prior read more

June 25Rotator Cuff WP

Articles, Shoulder Pain

Degenerative disc disease, affecting one or more intervertebral discs, is often accompanied my severe neck (cervical) or lower back (lumbar) pain or sciatica. The degenerative disease has a high prevalence and represents a major public health problem with high socio-economic impact. Once degeneration starts, it is difficult to reverse, and there is no effective treatment read more

June 25Bone Marrow Aspirate in the treatment of Osteonecrosis

Articles, Hip Pain

At our institution, hip decompression with the introduction of concentrated bone marrow and platelet rich plasma was performed on 73 hips. Patients were followed for an average of 17 months. Twenty-five patients underwent unilateral decompression and 24 underwent bilateral decompression. Preoperative x-rays and MRI was obtained on all patients. Thirty-six left hips and 37 right read more

June 25Autologous Adipose Tissue-Derived Stem Cells Induce Persistent Bone-Like Tissue in Osteonecrotic Femoral Heads

Articles, Hip Pain

Background: Osteonecrosis also know as avascular necrosis, of the femoral head is a debilitating discover that commonly affects 30 to 50-year-old individuals. Download article here.

June 25AM and AF in Nerve Regeneration

Articles, Foot & Ankle

Peripheral nerve injury is a devastating complication that can lead to complete functional loss or permanent impairment. Despite significant advances in the repair of peripheral nerves, the functional recovery of these nerves never returns to the pre-injury state. Therefore, there have been many experimental trials to repair injured nerves. Recently, alternative materials embedded with regenerative read more

June 25Re-exploration after Posterior Lumbar Instrumentation

Articles, Back & Spine

The use of human amniotic membrane based products has also been considered for the prevention of epidural fibrosis. Amniotic membrane, comprised of both amnion and chorion membranes, is metabolically active tissue which continually remodels the extra cellular matrix through processes controlled by paracrine growth factors. Amnion has 5 layers including epithelium, basement membrane, compact layer, read more

June 25Implantation of amniotic membrane to reduce postlaminectomy

Articles, Back & Spine

Approximately 185,000 lumbar spine surgeries are performed every year in the US to treat various clinical conditions such as spondylolisthesis, spinal stenosis, and disco genic back pain. Failed back surgery syndrome (FBSS) is characterized by the presence of intractable pain and varying degrees of functional incapacity after lumbar spine surgery. It occurs in 13–61% of read more

June 25Stem Cell Injection of Foot & Ankle

Articles, Foot & Ankle

We performed a prospective randomized clinical trial comparing improvement of plantar fasciitis symptoms in patients receiving standard of care treatment alone versus standard of care with the injection of a mDHACM allograft (AmnioFix Injectable, MiMedx Group Inc, Marietta, GA). The study was conducted at a single center in southwest Virginia under the direction of a senior clinician read more

June 25Amniotic Membrane Tissue During Repair of Posterior Tibial & Achilles Tendons

Articles, Foot & Ankle

Connective tissues that become damaged or diseased can result in reduced mobility and contribute to the development of chronic pain. While conservative treatment approaches are often helpful, many patients become debilitated and require surgical intervention.  As a result of the widespread prevalence of these conditions, procedures to repair and reconstruct damaged connective tissue are common-place. read more

June 25AM and AF in Nerve Regeneration

Articles, Foot & Ankle

Peripheral nerve injury is a devastating complication that can lead to complete functional loss or permanent impairment. Despite significant advances in the repair of peripheral nerves, the functional recovery of these nerves never returns to the pre-injury state. Therefore, there have been many experimental trials to repair injured nerves. Recently, alternative materials embedded with regenerative read more

June 25Autologous Bone Marrow Plasma Injection after Arthroscopic Debridement for Elbow Tendosis

Articles, Uncategorized

The treatment of tendinosis of elbow can be challenging, yet rewarding. Nevertheless, for the patients who failed conservative management and develop persistent recalcitrant symptoms, surgical intervention should be considered. The hypothesis of this study is iliac bone marrow plasma injection after arthroscopic debridement of degenerative tissue will bring along biological cure. Thus, it will not read more

June 22Dan Crane, APEX Biologix President, Travels to London to attend the World Stem Cells and Regenerative Medicine Congress

Articles, Uncategorized

The World Stem Cells and Regenerative Medicine Congress brings together scientists, leaders, developers, and doctors from all over the world to share their thoughts, ideas, and research topics surrounding stem cells. Daniel Crane, President of Apex Biologix, and Matthew Peterson, MD, of the Algone Center in Alaska, had the great opportunity to be a part read more

June 22Adult Stem Cell Training

Articles, Uncategorized

Stem cell therapy is trailblazing the world of pain medicine. Patients of adult stem cell therapy procedures are making their successful treatments the talk of the town. Success stories are being created day after day, and not only are patients being benefitted, but the physicians and clinics that perform them are too. There is a read more

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